{"id":32642,"date":"2015-11-09T11:49:00","date_gmt":"2015-11-09T09:49:00","guid":{"rendered":"http:\/\/www.floracantabrica.com\/?p=32642"},"modified":"2018-10-21T20:01:11","modified_gmt":"2018-10-21T18:01:11","slug":"tratamiento-pionero-con-celulas-de-diseno-revierte-leucemia-en-una-nina-de-1-ano-pioneer-design-cells-treatment-reverses-leukemia-in-a-girl-of-1-year","status":"publish","type":"post","link":"https:\/\/www.floracantabrica.com\/?p=32642","title":{"rendered":"…Tratamiento pionero con c\u00e9lulas de dise\u00f1o revierte leucemia en una ni\u00f1a de 1 a\u00f1o…"},"content":{"rendered":"

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Tratamiento pionero con c\u00e9lulas de dise\u00f1o revierte leucemia en una ni\u00f1a de 1 a\u00f1o<\/span><\/strong><\/p>\n

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Pioneer<\/strong> design cells treatment reverses leukemia in a girl of 1 year<\/strong><\/span><\/p>\n

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BBC Mundo<\/strong><\/span><\/p>\n

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Hace apenas cinco meses Layla Richards, de tan solo 1 a\u00f1o, padec\u00eda de un tipo de leucemia agresiva incurable.<\/strong><\/span><\/p>\n

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\/**\/ if (window.bbcdotcom && bbcdotcom.slot) { bbcdotcom.slot(‘mpu’, [3]); } \/**\/ \/**\/ if (window.bbcdotcom && bbcdotcom.show) { bbcdotcom.show() } \/**\/ Los m\u00e9dicos en Reino Unido no ten\u00edan nada m\u00e1s que ofrecer y como \u00faltimo recurso intentaron una terapia gen\u00e9tica pionera, cuyos resultados han calificado de \u00abcasi milagrosos\u00bb.<\/span><\/p>\n

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Los especialistas utilizaron \u00abc\u00e9lulas inmunes dise\u00f1adas\u00bb para combatir el c\u00e1ncer de Layla.<\/span><\/p>\n

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Es muy pronto para decir si est\u00e1 curada, pero los progresos que ha tenido ya significan -para los especialistas- un gran avance en la lucha contra el c\u00e1ncer.<\/span><\/p>\n

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Layla fue diagnosticada con la enfermedad a los 3 meses de haber nacido en Londres..,<\/span><\/p>\n

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Como suele suceder en beb\u00e9s tan peque\u00f1os, la quimioterapia y el trasplante de m\u00e9dula no pudieron curarla.<\/span><\/p>\n

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Al no tener m\u00e1s opciones, el d\u00eda antes del primer cumplea\u00f1os de la peque\u00f1a, los especialistas le dijeron a los padres que lo \u00fanico que quedaba ahora era el cuidado paliativo.<\/span><\/p>\n

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Pero el padre de Layla, Ashleigh, se neg\u00f3 a arrojar la toalla.<\/span><\/p>\n

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\u00abNo quer\u00eda ir por ese camino, prefer\u00eda que trataran algo nuevo y me arriesgu\u00e9\u00bb, le dijo a la BBC.<\/span><\/p>\n

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\u00abY as\u00ed est\u00e1 ella hoy en d\u00eda, riendo y en pie. Antes del tratamiento estaba tan d\u00e9bil… era horrible. Sencillamente estoy muy agradecido por esta oportunidad\u00bb.<\/span><\/p>\n

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Tijeras microsc\u00f3picas<\/strong><\/span><\/p>\n

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Para llegar a este momento, el personal m\u00e9dico, en conjunto con la empresa de biotecnolog\u00eda Cellectics, se apresur\u00f3 a obtener todos los permisos necesarios para probar una terapia altamente experimental que s\u00f3lo se hab\u00eda hecho en ratones.<\/span><\/p>\n

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Image caption El tra<\/span><\/p>\n

……tamiento consisti\u00f3 en cambiar los genes de las c\u00e9lulas inmunes<\/span><\/p>\n

El tratamiento, que consiste en dise\u00f1ar c\u00e9lulas inmunes, es el resultado de los avances que se han hecho en edici\u00f3n de genes.<\/span><\/p>\n

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Terapias anteriores hab\u00edan intentado a\u00f1adir genes nuevos para corregir un defecto, mientras que esta consisti\u00f3 en editar los genes que ya estaban ah\u00ed.<\/span><\/p>\n

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Para ello, en las c\u00e9lulas inmunes del donante se utilizaron unas tijeras microsc\u00f3picas, conocidas como Talen.<\/span><\/p>\n

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Estas c\u00e9lulas fueron dise\u00f1adas para hacerlas invisibles a los fuertes f\u00e1rmacos que se le suministra a los pacientes y para \u00fanicamente buscar y exterminar las c\u00e9lulas de la leucemia.<\/span><\/p>\n

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Las c\u00e9lulas dise\u00f1adas fueron inyectadas en Layla. Adem\u00e1s necesit\u00f3 de un segundo trasplante de m\u00e9dula para restablecer su sistema inmune.<\/span><\/p>\n

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Ahora, tan s\u00f3lo meses despu\u00e9s de que le dieran a su familia la devastadora noticia de que el c\u00e1ncer era incurable, Layla no solo est\u00e1 viva, sino que no hay rastro de leucemia en su cuerpo.<\/span><\/p>\n

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\u00abCasi como un milagro\u00bb<\/strong><\/span><\/p>\n

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El doctor Paul Veys, del hospital Great Ormond Street de Londres, considera la transformaci\u00f3n de Layla como una de las cosas m\u00e1s extraordinarias que haya visto en 20 a\u00f1os.<\/span><\/p>\n

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Image caption Los exp<\/span><\/p>\n

……ertos advierten que hay que esperar unos a\u00f1os, y hacer m\u00e1s estudios, antes de hablar de cura.<\/span><\/p>\n

\u00abEstamos en una posici\u00f3n maravillosa, comparado a como est\u00e1bamos hace cinco meses. Pero esto no significa que se haya curado\u00bb, aclar\u00f3 Veys. \u00abLa \u00fanica forma de saber si se trata de una cura es esperar uno o dos a\u00f1os. Pero haber llegado hasta este punto es un paso muy, muy grande\u00bb.<\/span><\/p>\n

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El especialista agrega que el caso es \u00abcasi como un milagro\u00bb.<\/span><\/p>\n

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La historia de Layla fue presentada en la Sociedad Americana de Hematolog\u00eda, pero este es solo un caso que no ha sido sometido a pruebas cl\u00ednicas.<\/span><\/p>\n

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Sin embargo, expertos coinciden en que el ritmo del progreso en la tecnolog\u00eda de edici\u00f3n de genes es fenomenal.<\/span><\/p>\n

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\u00abEsta es la primera vez que c\u00e9lulas humanas, modificadas de esta forma, han sido administradas a un paciente, y este es un gran paso para nosotros\u00bb, se\u00f1al\u00f3 el profesor Waseem Qasim del Great Ormond Street.<\/span><\/p>\n

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\u00abLa tecnolog\u00eda avanza muy r\u00e1pido, de repente la habilidad de dirigirse a regiones muy espec\u00edficas del genoma se ha hecho mucho m\u00e1s eficiente y creemos que esta tecnolog\u00eda estar\u00e1 en la siguiente fase de tratamientos\u00bb, agreg\u00f3.<\/span><\/p>\n

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Only five months ago Layla Richards, only 1 year, suffered from a type of incurable aggressive leukemia.<\/span><\/p>\n

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\nUnited Kingdom doctors had nothing more to offer, and as a last resort tried to a gene therapy pioneer, whose results have been described as \u00abalmost miraculous\u00bb.<\/span><\/p>\n

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Specialists used \u00abimmune cells designed\u00bb to fight the cancer of Layla.<\/span><\/p>\n

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It is too soon to tell if it is cured, but the progress that has been already meant – for specialists – a breakthrough in the fight against cancer.<\/span><\/p>\n

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Layla was diagnosed with the disease three months of having been born in London.<\/span><\/p>\n

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As it is often the case in such small babies, chemotherapy and bone marrow transplant not could cure it.<\/span><\/p>\n

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Having no more options, the day before the first birthday of the small, specialists told parents that all that was left now was palliative care.<\/span><\/p>\n

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But the father of Layla, Ashleigh, refused to throw in the towel.<\/span><\/p>\n

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\u00abI didn’t want to go down that road, preferred to treat something new, and I took a risk,\u00bb he said to the BBC.<\/span><\/p>\n

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\u00abAnd so is she today, laughing and standing.\u00bb Before the treatment was so weak… was horrible. I’m just grateful for this opportunity\u00bb.<\/span><\/p>\n

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Microscopic scissors<\/span><\/p>\n

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To get to this point, medical personnel, in conjunction with the company’s biotechnology Cellectics, rushed to get all the permits necessary to prove a highly experimental therapy that only has been done in mice.<\/span><\/p>\n

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Laboratory<\/span><\/p>\n

Image caption<\/span><\/p>\n

The treatment consisted of changing the genes of the immune cells<\/span><\/p>\n

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The treatment, which consists of designing immune cells, is the result of the advances that have been made in edition of genes.<\/span><\/p>\n

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Previous therapies had tried to add new genes to correct a defect, while this consisted of editing the genes that were already there.<\/span><\/p>\n

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Therefore in the immune cells of the donor were microscopic scissors, known as Talen.<\/span><\/p>\n

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These cells were designed to make them invisible to strong drugs supplied to patients and to only find and kill the leukemia cells.<\/span><\/p>\n

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Designed cells were injected into Layla. It also needed a second marrow transplant to restore his immune system.<\/span><\/p>\n

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Now, just months after they gave her family the devastating news that the cancer was incurable, Layla not only is alive, but that there is no trace of leukemia in his body.<\/span><\/p>\n

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\u00abLike a miracle\u00bb<\/span><\/p>\n

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Doctor Paul Veys, London’s Great Ormond Street Hospital, believes the transformation of Layla as one of the most extraordinary things he has seen in 20 years.<\/span><\/p>\n

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Parents of Layla Layla<\/span><\/p>\n

Image caption<\/span><\/p>\n

Experts warn that you necessary to wait a few years and do more studies before we talk about cure.<\/span><\/p>\n

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\u00abWe are in a wonderful position, compared to as we were five months ago.\u00bb But this does not mean that it has healed,\u00bbsaid Veys. \u00abThe only way to know if it’s a cure is wait one or two years. \u00abBut having come this far is a step very, very big\u00bb.<\/span><\/p>\n

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The specialist added that the case is \u00abalmost like a miracle\u00bb.<\/span><\/p>\n

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The story of Layla was presented at the American Society of Hematology, but this is only one case that has not been subjected to clinical trials.<\/span><\/p>\n

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However, experts agree that the pace of progress in the editing of gene technology is phenomenal.<\/span><\/p>\n

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\u00abThis is the first time that human cells, modified in this way, have been administered to a patient, and this is a big step for us,\u00bb said Professor Waseem Qasim the Great Ormond Street.<\/span><\/p>\n

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\u00abTechnology moves very fast, suddenly the ability to refer to very specific regions of the genome has become much more efficient and we believe that this technology will be in the next phase of treatment,\u00bb he added.<\/span><\/p>\n

\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Tweet………………..   Tratamiento pionero con c\u00e9lulas de dise\u00f1o revierte leucemia en una ni\u00f1a de 1 a\u00f1o \u00a0 ……. ……..       …… Pioneer design cells treatment reverses leukemia in a girl of 1 year ……….. …….. BBC Mundo …….. …… Hace apenas cinco meses Layla Richards, de tan solo 1 a\u00f1o, padec\u00eda de un […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,5,7],"tags":[],"class_list":["post-32642","post","type-post","status-publish","format-standard","hentry","category-divulgacion","category-etnopaisaje","category-mis-dibujos"],"_links":{"self":[{"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/posts\/32642","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=32642"}],"version-history":[{"count":3,"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/posts\/32642\/revisions"}],"predecessor-version":[{"id":43016,"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/posts\/32642\/revisions\/43016"}],"wp:attachment":[{"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=32642"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=32642"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=32642"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}