{"id":20039,"date":"2012-07-22T21:50:46","date_gmt":"2012-07-22T19:50:46","guid":{"rendered":"http:\/\/www.floracantabrica.com\/?p=20039"},"modified":"2012-07-22T22:01:18","modified_gmt":"2012-07-22T20:01:18","slug":"identifican-una-proteina-clave-en-la-insuficiencia-cardiaca-they-identified-a-key-protein-in-heart-failure%c2%b4","status":"publish","type":"post","link":"https:\/\/www.floracantabrica.com\/?p=20039","title":{"rendered":"Identifican una prote\u00edna clave en la insuficiencia cardiaca.They identified a key protein in heart failure\u00b4"},"content":{"rendered":"

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Identifican una prote\u00edna clave en la insuficiencia cardiaca.<\/strong><\/span><\/p>\n

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They identified a key protein in heart failure\u00b4<\/strong><\/span><\/p>\n

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Dependiendo de c\u00f3mo se lleve a cabo, la activaci\u00f3n de la prote\u00edna APJ<\/strong> podr\u00eda empeorar la condici\u00f3n de los pacientes con enfermedad del coraz\u00f3n.<\/span><\/p>\n

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Un equipo del Instituto de Investigaci\u00f3n M\u00e9dica Sanford-Burnham, y la Universidad de Stanford (EE.UU.), han descubierto que los cambios en la salud cardiaca dependen de la forma en que se activa una prote\u00edna del coraz\u00f3n<\/strong>. Esta informaci\u00f3n, seg\u00fan un estudio que se publica en Nature<\/em><\/a>, puede abrir una nueva de investigaci\u00f3n para desarrollar f\u00e1rmacos para tratar las enfermedades cardiovasculares<\/strong><\/span><\/p>\n

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La prote\u00edna cardiaca APJ ha<\/strong> sido profusamente estudiada en los \u00faltimos a\u00f1os. En este trabajo, los investigadores han descubierto una segunda funci\u00f3n<\/strong>, previamente desconocida de la prote\u00edna APJ: APJ es capaz de detectar los cambios mec\u00e1nicos<\/strong> cuando el coraz\u00f3n est\u00e1 en peligro, lo que conduce hacia la insuficiencia cardiaca<\/a><\/strong><\/span><\/p>\n

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Esto, aseguran los investigadores, significa que la activaci\u00f3n de APJ, en realidad, podr\u00eda ser perjudicial en algunos caso<\/strong>s. \u00abS\u00f3lo la b\u00fasqueda de una mol\u00e9cula que active la APJ no es suficiente. Lo que es importante para la insuficiencia cardiaca no es si este receptor est\u00e1 activado o desactivado, sino la forma en que se activa<\/strong>\u00bb, afirma Pilar Ruiz-Lozano, profesora en Stanford, quien dirigi\u00f3 el estudio.<\/span><\/p>\n

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Cuando una hormona llamada apelina se une a la APJ<\/strong>, se desencadena una reacci\u00f3n en cadena que influye en una serie de funciones celulares. Estudios anteriores han demostrado que la actividad de la apelina-APJ dirige procesos beneficiosos<\/strong>, tales como el desarrollo embrionario del coraz\u00f3n, el mantenimiento de la presi\u00f3n arterial normal<\/strong>, y la formaci\u00f3n de nuevos vasos sangu\u00edneos. Sin embargo, seg\u00fan el nuevo estudio, la APJ tambi\u00e9n puede ser activada de una forma da\u00f1ina<\/strong>, que no implica a la apelina, en la que responde a los cambios mec\u00e1nicos del coraz\u00f3n<\/span><\/p>\n

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Seg\u00fan este hallazgo, dependiendo de c\u00f3mo se lleve a cabo, la activaci\u00f3n de APJ podr\u00eda empeorar la condici\u00f3n de los pacientes con enfermedad del coraz\u00f3n<\/span><\/p>\n

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When a hormone called apelin joins the APJ, triggers a chain reaction that affects a series of cellular function<\/strong>s. Previous studies have shown that the activity of apelin-APJ directs beneficial processes, such as the embryonic development of the heart, the maintenance of normal blood pressure, and the formation of new blood vessels. However, according to the new study, the APJ may also be activated in a harmful way, that does not involve the apelin, which responds to the mechanical changes of the heart<\/span><\/p>\n

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. Depending on how you carry out, the activation of the APJ protein could worsen the condition of patients with heart disease<\/span><\/p>\n

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. A team of the Sanford-Burnham Medical Research Institute and Stanford University (USA).(UU.), have discovered that changes in heart health depend upon the way in which activates a protein of the heart. This information, according to a study published in Nature, can open a new research to develop drugs to treat cardiovascular diseases<\/span><\/p>\n

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The APJ heart protein has been extensively studied in recent years. In this work, researchers have discovered a second function, previously unknown of the APJ protein: APJ is capable of detecting mechanical changes when the heart is in danger, that leads to heart failure<\/span><\/p>\n

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This, say the researchers, means that activation of APJ, might actually be harmful in some cases. \u00abOnly the search of a molecule that triggers the APJ is not enough.\u00bb \u00abWhat is important for heart failure is not if this receiver is enabled or disabled, but the way that fires\u00bb, says Pilar Ruiz-Lozano, Professor at Stanford, who directed the study.<\/span><\/p>\n

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When a hormone called apelin joins the APJ, triggers a chain reaction that affects a series of cellular functions. Previous studies have shown that the activity of apelin-APJ directs beneficial processes, such as the embryonic development of the heart, the maintenance of normal blood pressure, and the formation of new blood vessels. However, according to the new study, the APJ may also be activated in a harmful way, that does not involve the apelin, which responds to the mechanical changes of the heart<\/span><\/p>\n

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According to this finding, depending on how you carry out, the activation of APJ could worsen the condition of patients with heart disease.<\/span><\/p>\n

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Tweet…………. Identifican una prote\u00edna clave en la insuficiencia cardiaca. ,,,, ,,,,, ,,, They identified a key protein in heart failure\u00b4 …….. ABC ….. Etnopaisaje.com ….. ……….. Dependiendo de c\u00f3mo se lleve a cabo, la activaci\u00f3n de la prote\u00edna APJ podr\u00eda empeorar la condici\u00f3n de los pacientes con enfermedad del coraz\u00f3n. \u2026\u2026\u2026\u2026 ……. Un equipo del […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-20039","post","type-post","status-publish","format-standard","hentry","category-etnopaisaje"],"_links":{"self":[{"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/posts\/20039","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=20039"}],"version-history":[{"count":9,"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/posts\/20039\/revisions"}],"predecessor-version":[{"id":20048,"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/posts\/20039\/revisions\/20048"}],"wp:attachment":[{"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=20039"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=20039"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=20039"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}