{"id":20023,"date":"2012-07-22T14:59:34","date_gmt":"2012-07-22T12:59:34","guid":{"rendered":"http:\/\/www.floracantabrica.com\/?p=20023"},"modified":"2012-07-22T14:59:34","modified_gmt":"2012-07-22T12:59:34","slug":"crean-un-raton-con-el-sistema-inmune-humano-que-podria-revolucionar-la-investigacion-en-vih-create-a-mouse-with-the-human-immune-system-that-could-revolutionize-research-in-hiv","status":"publish","type":"post","link":"https:\/\/www.floracantabrica.com\/?p=20023","title":{"rendered":"Crean un rat\u00f3n con el sistema inmune humano que podr\u00eda revolucionar la investigaci\u00f3n en VIH. Create a mouse with the human immune system that could revolutionize research in HIV"},"content":{"rendered":"

Tweet<\/a><\/p>

…………<\/p>\n

Crean un rat\u00f3n con el sistema inmune humano que podr\u00eda revolucionar la investigaci\u00f3n en VIH<\/span><\/strong><\/p>\n

<\/span><\/p>\n

\u2026<\/span><\/p>\n

<\/span><\/p>\n

\u2026..<\/span><\/p>\n

<\/span><\/p>\n

Create a mouse with the human immune system that could revolutionize research in HIV<\/span><\/strong><\/p>\n

<\/span><\/strong><\/p>\n

\u2026\u2026<\/span><\/strong><\/p>\n

<\/span><\/p>\n

\u2026\u2026<\/span><\/p>\n

<\/span><\/p>\n

<\/span><\/p>\n

<\/span><\/p>\n

ABC<\/span><\/p>\n

<\/span><\/p>\n

\u2026\u2026<\/span><\/p>\n

<\/span><\/p>\n

..<\/span><\/p>\n

<\/span><\/p>\n

Etnopaisaje.com<\/strong><\/span><\/p>\n

<\/span><\/p>\n

\u2026\u2026\u2026<\/span><\/p>\n

<\/span><\/p>\n

\"image002\"<\/p>\n

\u2026\u2026<\/span><\/p>\n

<\/span><\/p>\n

Disponer de un modelo animal que reproduzca la respuesta inmune humana contra el VIH <\/a>puede simplificar los ensayos de <\/strong>vacunas contra el virus del sid<\/strong>a<\/a> y, seg\u00fan un trabajo que se publica en Science Translational Medicine<\/a>, revolucionar la investigaci\u00f3n<\/strong> que persigue una vacuna contra este mortal virus.<\/span><\/p>\n

<\/span><\/p>\n

\u2026\u2026<\/span><\/p>\n

<\/span><\/p>\n

\u2026\u2026<\/span><\/p>\n

<\/span><\/p>\n

,,,,,<\/span><\/p>\n

<\/span><\/p>\n

,,,,,,<\/span><\/p>\n

<\/span><\/p>\n

Uno de los retos para el desarrollo de vacunas <\/a>contra el VIH ha sido la falta de un modelo animal que refleje con precisi\u00f3n la respuesta inmune de los humano<\/strong>s antes virus que sirva para estudiar c\u00f3mo evoluciona el virus para poder evadirse <\/a>de dicha respuesta. En este trabajo, desarrollado por investigadores del Instituto Ragon del Hospital General de Massachusetts y de la Universidad de Harvard (EE.UU.) se describe un modelo de animal humanizado<\/strong>, creado gracias el trasplante de los elementos del sistema inmune humano en un rat\u00f3<\/strong>n, que podr\u00eda servir de base para probar <\/strong>los nuevos candidatos<\/span><\/p>\n

<\/span><\/p>\n

<\/span><\/p>\n

<\/span><\/p>\n

<\/span><\/p>\n

<\/span><\/p>\n

…..<\/span><\/p>\n

<\/span><\/p>\n

……<\/span><\/p>\n

<\/span><\/p>\n

……<\/span><\/p>\n

<\/span><\/p>\n

…<\/span><\/p>\n

<\/span><\/p>\n

Evasi\u00f3n del VIH<\/strong><\/span><\/p>\n

<\/span><\/p>\n

\u2026\u2026<\/strong><\/span><\/p>\n

<\/span><\/p>\n

\u2026<\/strong><\/span><\/p>\n

<\/span><\/p>\n

<\/span><\/p>\n

<\/span><\/p>\n

El trabajo ha demostrado que los ratones humanizados son capaces de presentar una respuesta inmune frente a la infecci\u00f3n por VIH; <\/strong>pero tambi\u00e9n, explica Tod Allen, coordinador del trabajo, \u00abnos ha indicado la capacidad del VIH para evadir dicha respuesta<\/strong> mediante la mutaci\u00f3n de las prote\u00ednas virales espec\u00edficas de las c\u00e9lulas<\/strong> T CD8 asesinas\u00bb. Allen subraya que \u00abpor vez primera\u00bb tenemos un modelo animal que \u00abreproduce con precisi\u00f3n las interacciones cr\u00edticas entre el hu\u00e9sped-pat\u00f3geno, un modelo que sin duda ayudar\u00e1 a facilitar el desarrollo de una vacuna eficaz contra el VIH<\/span><\/p>\n

<\/span><\/p>\n

…..<\/span><\/p>\n

<\/span><\/p>\n

…<\/span><\/p>\n

.<\/span><\/p>\n

.
\n<\/span><\/p>\n

<\/span><\/p>\n

Ahora -dice Allen- sabemos que estos ratones parecen reproducir la especificidad de la respuesta celular de los humanos ante el VIH<\/strong> y, adem\u00e1s, que el virus intenta eludir estas respuestas tal como lo hace en los seres humanos\u00bb. En su opini\u00f3n, el siguiente paso ser\u00e1 ver si es posible inducir una respuesta espec\u00edfica inmune humana frente al VIH mediante su vacunaci\u00f3n<\/strong><\/span><\/p>\n

<\/span><\/p>\n

\u2026<\/strong><\/span><\/p>\n

\u2026<\/strong><\/span><\/p>\n

\u2026<\/strong><\/span><\/p>\n

.<\/strong><\/span><\/p>\n

<\/span><\/p>\n

we have an animal model that reproduces the human immune response against HIV can simplify the trials of vaccines against the AIDS virus, according to a work that is published in Science Translational Medicine, revolutionize the research pursued by a vaccine against this deadly virus<\/span><\/p>\n

<\/span><\/p>\n

……<\/span><\/p>\n

……<\/span><\/p>\n

<\/span><\/p>\n

One of the challenges for HIV vaccine development has been the lack of an animal model that accurately reflects the human immune response before virus that serve to study how it evolves the virus to be able to evade this response. In this work, developed by researchers from the Ragon Institute of the General Hospital of Massachusetts and Harvard University (USA).(UU.) Describes a model of Humanized animal created thanks the transplant of the elements of the human immune system into a mouse, which could serve as a basis to test the new candidates<\/span><\/p>\n

<\/span><\/p>\n

…….<\/strong><\/span><\/p>\n

…….<\/strong><\/span><\/p>\n

..<\/strong><\/span><\/p>\n

<\/span><\/p>\n

HIV escape<\/span><\/p>\n

<\/span><\/p>\n

….<\/span><\/p>\n

<\/span><\/p>\n

….<\/span><\/p>\n

<\/span><\/p>\n

<\/span><\/p>\n

<\/span><\/p>\n

<\/span><\/p>\n

<\/span><\/p>\n

The work has shown that humanized mice are able to present an immune response against HIV infection; but, explained Tod Allen, Coordinator of the work, \u00abhas also indicated us the ability of HIV to evade this response through the mutation of specific viral proteins of T CD8 killer cells\u00bb. Allen stressed that \u00abfor the first time\u00bb we have an animal model that \u00abaccurately reproduces the critical interactions between huesped-patogeno, a model that will certainly help to facilitate the development of an effective vaccine against HIV\u00bb<\/span><\/p>\n

<\/span><\/p>\n

…..<\/span><\/p>\n

<\/span><\/p>\n

\u2026\u2026<\/strong><\/span><\/p>\n

<\/span><\/p>\n

\u00ab- Says Allen – we now know that these mice seem to play the specificity of the human cellular response against HIV and, in addition, that the virus attempts to circumvent these responses as it does in humans\u00bb. In his view, the next step is to see if it is possible to induce a human specific immune response against HIV through its vaccination<\/span><\/p>\n

…….<\/span><\/p>\n


\n<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Tweet………… Crean un rat\u00f3n con el sistema inmune humano que podr\u00eda revolucionar la investigaci\u00f3n en VIH \u2026 \u2026.. Create a mouse with the human immune system that could revolutionize research in HIV \u2026\u2026 \u2026\u2026 ABC \u2026\u2026 .. Etnopaisaje.com \u2026\u2026\u2026 \u2026\u2026 Disponer de un modelo animal que reproduzca la respuesta inmune humana contra el VIH puede […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-20023","post","type-post","status-publish","format-standard","hentry","category-etnopaisaje"],"_links":{"self":[{"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/posts\/20023","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=20023"}],"version-history":[{"count":8,"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/posts\/20023\/revisions"}],"predecessor-version":[{"id":20033,"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/posts\/20023\/revisions\/20033"}],"wp:attachment":[{"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=20023"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=20023"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.floracantabrica.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=20023"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}