{"id":25199,"date":"2013-07-19T12:29:55","date_gmt":"2013-07-19T10:29:55","guid":{"rendered":"http:\/\/www.floracantabrica.com\/?p=25199"},"modified":"2013-07-19T12:29:55","modified_gmt":"2013-07-19T10:29:55","slug":"hallan-un-metodo-para-desactivar-el-cromosoma-responsable-del-sindrome-de-down-they-are-a-method-to-disable-the-chromosome-responsible-for-down-syndrome","status":"publish","type":"post","link":"http:\/\/www.floracantabrica.com\/?p=25199","title":{"rendered":"Hallan un m\u00e9todo para desactivar el cromosoma responsable del s\u00edndrome de Down.They are a method to disable the chromosome responsible for Down syndrome"},"content":{"rendered":"

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Hallan un m\u00e9todo para desactivar el cromosoma responsable del s\u00edndrome de Down<\/span><\/span><\/strong><\/span><\/p>\n

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They are a method to disable the chromosome responsible for Down syndrome<\/span><\/strong><\/span><\/p>\n

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Por primera vez en historia, cient\u00edficos de EE.UU. descubren la posibilidad de neutralizar el cromosoma responsable del s\u00edndrome de Down en<\/strong> c\u00e9lulas madre de laboratorio.
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Los cient\u00edficos de la Escuela de Medicina de la Universidad de Massachusetts, EE.UU., han demostrado que es posible hallar una forma natural de desactivar\u00a0el cromosoma responsable de la trisom\u00eda del cromosoma 21, tambi\u00e9n conocida como ‘s\u00edndrome de Down’<\/strong>, un trastorno gen\u00e9tico caracterizado por un\u00a0deterioro cognitivo<\/span><\/a>. <\/span><\/span><\/p>\n

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Los resultados del estudio, publicados en la revista ‘Nature’, ofrecen<\/strong> nuevos modelos celulares para desarrollar posibles t\u00e9cnicas de tratamiento, seg\u00fan los investigadores. <\/span><\/p>\n

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\u00abLa \u00faltima d\u00e9cada ha sido testigo de grandes avances en los esfuerzos para corregir los trastornos de un solo gen a partir de c\u00e9lulas in vitro,<\/strong> y en varios casos tambi\u00e9n de avances en ensayos cl\u00ednicos y en vivo\u00bb, afirma la autora principal del estudio, Jeanne B. Lawrence, profesora de biolog\u00eda celular y del desarrollo en la Universidad de Massachusetts.<\/span><\/p>\n

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\nLos seres humanos nacen con 23 pares de cromosomas, incluyendo dos cromosomas sexuales, lo que supone un total de 46 en cada c\u00e9lula. Las personas con s\u00edndrome de Down nacen con tres (y no dos) copias del cromosoma 21<\/span><\/a>, y esta trisom\u00eda 21 es responsable de discapacidades cognitivas<\/strong>, un inicio temprano del Alzheimer y otras enfermedades. A diferencia de los trastornos gen\u00e9ticos causados por un solo gen, la correcci\u00f3n gen\u00e9tica de un cromosoma entero en c\u00e9lulas tris\u00f3micas todav\u00eda es imposible<\/span>, incluso en c\u00e9lulas cultivadas.<\/span><\/span><\/p>\n

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La aplicaci\u00f3n m\u00e1s inmediata del descubrimiento es poder estudiar c\u00f3mo el cromosoma extra afecta el desarrollo de las c\u00e9lulas, seg\u00fan Lawrence. <\/span><\/span><\/p>\n

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\u00abEsperamos que, a largo plazo, la terapia cromos\u00f3mica pueda aplicarse a algunos aspectos de la enfermedad\u00bb, dijo. Eso podr\u00eda ocurrir dentro de una d\u00e9cada, a\u00f1adi\u00f3. <\/span><\/p>\n

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Debido a que la t\u00e9cnica no funcionar\u00eda<\/span> en todas las c\u00e9lulas del cuerpo, la terapia g\u00e9nica basada en este trabajo solo podr\u00eda ser utilizada para lograr efectos espec\u00edficos, tales como la reducci\u00f3n del riesgo de c\u00e1nceres de la sangre. Incluso una te<\/span><\/strong>rapia g\u00e9nica para el s\u00edndrome de Down no garantiza una curaci\u00f3n segura, se\u00f1al\u00f3.<\/span>
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For the first time in history, U.S. scientists.UU. they discover the ability to neutralize the <\/span>chromosome<\/span> responsible for Down syndrome on stem cells from laboratory.<\/span><\/span><\/p>\n

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Scientists at the school of Medicine of the University of Massachusetts, USA.UU., have shown that it is possible to find a natural way of disabling the chromosome responsible for trisomy of chromosome 21, also known as ‘Down syndrome’, a genetic disorder characterized by cognitive impairment.<\/span><\/span><\/p>\n

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The results of the study, published in the journal ‘Nature’, offer new cellular models for developing possible techniques of treatment, according to researchers.<\/span><\/span><\/p>\n

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\u00abThe last decade has witnessed great progress in efforts to correct disorders of a single gene from cells in vitro, and in some cases also of advances in clinical trials and live\u00bb, says the lead author of the study, Jeanne B. Lawrence, Professor of cell biology and development at the University of Massachusetts.<\/span><\/span><\/p>\n

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Humans are born with 23 pairs of chromosomes, including two sex chromosomes, resulting in a total of 46 in each cell. People with Down syndrome are born with three (and not two) copies of chromosome 21, and this trisomy 21 is responsible for cognitive disabilities, an early onset of Alzheimer’s and other diseases. Unlike genetic disorders caused by a single gene, the genetic correction of a whole chromosome in trisomic cells is still impossible, even in cultured cells.<\/span><\/span><\/p>\n

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,,,,,,<\/span>The most immediate application of the discovery is to study how the extra chromosome affects the development of cells, according to Lawrence.<\/span><\/span><\/p>\n

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\u00abWe hope that, in the long run, chromosomal therapy can be applied to some aspects of the disease,\u00bb he said. That could happen within a decade, he added.<\/span><\/span><\/p>\n

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Since the technique would not work in all cells of the body, based on this single gene therapy could be used to achieve specific effects, such as reducing the risk of cancers of the blood. Even a gene therapy for Down syndrome does not guarantee a safe cure, he said.<\/span><\/span><\/p>\n

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Tweet……………. Hallan un m\u00e9todo para desactivar el cromosoma responsable del s\u00edndrome de Down ….. ……… They are a method to disable the chromosome responsible for Down syndrome ……. ……… RT Actualidad \/ Ciencia …….. …. Etnopaisaje.com + dibujos. …….. . … . Por primera vez en historia, cient\u00edficos de EE.UU. descubren la posibilidad de neutralizar […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-25199","post","type-post","status-publish","format-standard","hentry","category-etnopaisaje"],"_links":{"self":[{"href":"http:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/posts\/25199","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.floracantabrica.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=25199"}],"version-history":[{"count":4,"href":"http:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/posts\/25199\/revisions"}],"predecessor-version":[{"id":25205,"href":"http:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/posts\/25199\/revisions\/25205"}],"wp:attachment":[{"href":"http:\/\/www.floracantabrica.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=25199"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/www.floracantabrica.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=25199"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.floracantabrica.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=25199"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}