{"id":20145,"date":"2012-07-29T17:01:34","date_gmt":"2012-07-29T15:01:34","guid":{"rendered":"http:\/\/www.floracantabrica.com\/?page_id=20145"},"modified":"2012-07-29T17:01:34","modified_gmt":"2012-07-29T15:01:34","slug":"a-drug-located-hiv-reservoirs-and-opens-the-door-to-eradicate-the-virus","status":"publish","type":"page","link":"http:\/\/www.floracantabrica.com\/?page_id=20145","title":{"rendered":"A drug located HIV reservoirs and opens the door to eradicate the virus"},"content":{"rendered":"

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Un f\u00e1rmaco localiza los reservorios del VIH y abre <\/span>la puerta para erradicar al virus<\/span><\/strong><\/p>\n

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ABC<\/strong><\/span><\/p>\n

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A drug located HIV reservoirs and opens the door to eradicate the virus<\/strong><\/span><\/p>\n

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Un f\u00e1rmaco utilizado para tratar ciertos tipos de linfoma parece<\/strong> ser capaz de destruir los reservorios de VIH <\/strong>escondidos y latentes en pacientes que reciben tratamiento antirretroviral.<\/span><\/p>\n

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La existencia de reservorios de VIH latentes persistentes en el sistema inmunol\u00f3gico<\/strong>, inaccesible para los tratamientos contra el virus, es una de las razones importantes por las que reaparece la infecci\u00f3n una vez que los pacientes dejan de tomar su medicaci\u00f3n. Los expertos saben que la eliminaci\u00f3n de dichos reservorios es fundamental para erradicar el virus y curar la enfermedad<\/strong><\/span><\/p>\n

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En el estudio, que publica Nature<\/em><\/a>, los investigadores de Universidad de Carolina del Norte en Chapel Hill (EE.UU.), en colaboraci\u00f3n con cient\u00edficos de la Escuela de Harvard de Salud P\u00fablica, Instituto Nacional del C\u00e1ncer, de Merck y la Universidad de California en San Diego, se detallan una serie de experimentos dise\u00f1ados para evaluar el potencial de vorinostat, un inhibidor de la deacetilasa que se utiliza para tratar algunos tipos de linfoma, para activar e interrumpir el virus latente<\/strong><\/span><\/p>\n

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Los resultados mostraron que, en los pacientes que recibieron vorinostat, la presencia de virus en sangre era 4.5 veces mayor que antes de recibir el f\u00e1rmaco<\/strong>, una evidencia de que el virus estaba siendo desenmascarado<\/strong>. Este es el primer estudio cl\u00ednico, en humanos, que demuestra el potencial de los inhibidores de deacetilasa para atacar a la latencia de los reservorios de virus latentes<\/span><\/p>\n

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\u00abEste trabajo proporciona evidencia convincente de una nueva estrategia para atacar directamente y erradicar la infecci\u00f3n latente por VIH<\/strong>\u00bb, subraya David Margolis. Seg\u00fan el experto, este puede ser un camino para curar <\/a>el sida,<\/span><\/p>\n

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A drug used to treat certain types of lymphoma seems to be able to destroy HIV reservoirs<\/strong> hidden and latent in patients receiving antiretroviral therapy.<\/span><\/p>\n

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The existence of persistent latent HIV reservoir in the immune system inaccessible for treatments against the virus, is one of the important reasons why reappears infection once patients stop taking their medication. Experts know that the Elimination of such reservoirs is essential to eradicate the virus and cure disease<\/span><\/p>\n

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In the study, published in Nature, researchers at the University of North Carolina at Chapel Hill (USA)(UU.), in collaboration with scientists from the Harvard School of public health, National Cancer Institute, of Merck and the University of California in San Diego, describes a series of experiments designed to evaluate the potential of vorinostat, an inhibitor of the deacetylase which is used to treat some types of lymphoma, to activate and stop the latent virus<\/span><\/p>\n

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The results showed that patients who received vorinostat, the presence of virus in blood was 4.5 times greater than before receiving the drug, evidence that the virus was being unmasked. This is the first clinical study in humans that demonstrates the potential of deacetylase inhibitors to attack the latency of the latent virus reservoirs<\/span><\/p>\n

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This work provides compelling evidence of a new strategy to directly attack and eradicate latent HIV infection\u00bb, emphasizes David Margolis. According to the expert, this can be a way to cure AIDS,<\/span><\/p>\n

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Tweet……………. Un f\u00e1rmaco localiza los reservorios del VIH y abre la puerta para erradicar al virus \u2026\u2026 ABC \u2026\u2026\u2026. A drug located HIV reservoirs and opens the door to eradicate the virus . . Etnopaisaje.com ………….. . …….. Un f\u00e1rmaco utilizado para tratar ciertos tipos de linfoma parece ser capaz de destruir los reservorios de […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"open","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-20145","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"http:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/pages\/20145","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.floracantabrica.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=20145"}],"version-history":[{"count":3,"href":"http:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/pages\/20145\/revisions"}],"predecessor-version":[{"id":20149,"href":"http:\/\/www.floracantabrica.com\/index.php?rest_route=\/wp\/v2\/pages\/20145\/revisions\/20149"}],"wp:attachment":[{"href":"http:\/\/www.floracantabrica.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=20145"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}